Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Donepezil increases angiogenic potential in patients with Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

A prokinetic agent DA-9701 formulated with Corydalis tuber and Pharbitidis semen improves nausea in migraine: A prospective observational study.

Medicine·2026
Same author

Effects of Artemisia asiatica ex on Akkermansia muciniphila dominance for modulation of Alzheimer's disease in mice.

PloS one·2024
Same author

Treatment Outcome After Switching From Galcanezumab to Fremanezumab in Patients With Migraine.

Journal of clinical neurology (Seoul, Korea)·2024
Same author

New era exploring the brain.

Encephalitis (Seoul, Korea)·2023
Same author

Efficacy and Safety of Galcanezumab as a Preventive Treatment for Episodic Migraine in South Korean Patients: A Post-Hoc Analysis of a Phase 3 Clinical Trial.

Journal of clinical neurology (Seoul, Korea)·2023

相关实验视频

Updated: Jun 13, 2026

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

16.3K

内皮原生细胞:一个简短的更新

Amna Rashid Tariq1, Mijung Lee1, Manho Kim1,2,3

  • 1Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.

International journal of stem cells
|November 29, 2023
PubMed
概括

内皮原生细胞 (EPC) 对于新血管生成和心血管健康至关重要. 本综述详细介绍了用于治疗应用的EPC扩展方法,包括隔离,分化和冷保存.

关键词:
CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34细胞培养技术 细胞培养技术内皮前代细胞是内皮前代细胞.细胞间信号传递和蛋白质.

更多相关视频

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

11.0K
Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

11.2K

相关实验视频

Last Updated: Jun 13, 2026

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood
13:46

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

16.3K
Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

11.0K
Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

11.2K

科学领域:

  • 细胞生物学 细胞生物学
  • 再生医学是一种再生医学.
  • 心血管研究研究心血管研究

背景情况:

  • 内皮原生细胞 (EPC) 在新血管生成中发挥着至关重要的作用,并与包括阿尔茨海默病在内的心血管风险有关.
  • 对EPC的治疗应用需要有效的方法来识别,隔离,分化和扩展它们.

研究的目的:

  • 审查和确定最可信和最快速的技术,以扩大内皮原生细胞 (EPC) 用于治疗.
  • 讨论EPC隔离,体外扩张,分化,冷保存和移植的方法.

主要方法:

  • 对骨髓和外围血液中EPC隔离技术的当前和以前报告的审查.
  • 分析涉及纤维内素涂层和EPC培养生长因子补充的方法.
  • 通过使用生长因子和内皮氧化合成酶来增强EPC分化策略的研究.

主要成果:

  • 可以使用纤维内丁涂层将EPCs分离出来,并使用生长因子进行增强.
  • 增长因子和内皮氧化合成酶可以促进EPC分化.
  • 在缺血性中风和急性脑梗塞的模型中,EPC移植已经显示出改善神经发生的潜力.

结论:

  • 有效的EPC体外扩展对于它们的治疗和移植应用至关重要.
  • 优化EPC扩张技术为心血管和神经疾病的临床应用提供了一个有前途的途径.
  • 需要进一步的研究来完善EPC扩展和移植协议,并确定关键生物标志物.