在患有代谢功能障碍相关的脂肪肝炎的患者处方基于证据的糖尿病药物治疗
Anastasia-Stefania Alexopoulos1,2,3, Alice Parish4, Maren Olsen2,4
1Department of Medicine, Division of Endocrinology, Duke University, Durham, North Carolina, USA asa61@duke.edu.
BMJ open diabetes research & care
|November 29, 2023
概括
在2型糖尿病 (T2D) 患者中,对代谢功能障碍相关的脂肪肝炎 (MASH) 基于证据的疗法的处方率较低. 这项研究发现,在处方皮奥格利塔或GLP-1RAs时,没有明显的种族或民族差异.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 临床药房 临床药房
背景情况:
- 代谢功能障碍相关的脂肪肝炎 (MASH) 经常与2型糖尿病 (T2D) 一起发生.
- 皮奥格利塔和葡萄糖类-1受体激动剂 (GLP-1RA) 是推的T2D治疗方法,可以解决MASH.
研究的目的:
- 评估T2D患者对MASH的基于证据的药物治疗 (EBP) 的处方率.
- 确定这些关键药物的处方中存在的任何种族或民族差异.
主要方法:
- 在2019年1月至2021年1月期间,对847名被诊断患有T2D和MASH的患者进行了一项横截面研究.
- 分析了皮奥格利塔和/或GLP-1RA的处方数据.
- 多变量后勤回归被用来检查不同种族和种族群体的处方模式.
主要成果:
- 只有34.8%的T2D和MASH患者接受了EBP.
- 处方率在种族/种族群体之间没有显著差异,包括拉丁裔/a/x和黑人患者与白人患者相比.
- 该研究发现,推药物治疗的整体利用率较低.
结论:
- 在T2D患者中,MASH的基于证据的药理疗法 (EBP) 未得到充分利用,不论种族或种族.
- 有必要进行干预措施,以改善对T2D中MASH治疗的基于证据的指导方针的遵守.
- 缩小当前实践和基于证据的护理之间的差距至关重要.
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