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Updated: Jul 9, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Published on: June 2, 2014

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25种急性偏头痛药物的同时比较基于1000万用户自报的智能手机应用程序记录

Chia-Chun Chiang1, Xuemin Fang1, Zsolt Horvath1

  • 1From the Department of Neurology (C.-C.C.), Mayo Clinic, Rochester, MN; Graduate School of Health Innovation (X.F., H.N.), Kanagawa University of Human Services, Kawasaki; IBM Client Engineering (X.F.), Banking Financial Market Unit, Chuo-Ku, Tokyo, Japan; Healint Pte. Ltd. (Z.H., F.C., A.U., W.P.), Singapore; Cancer Prevention and Cancer Control Division (H.N.), Kanagawa Cancer Center Research Institute; Department of Genetic Medicine (H.N.), Kanagawa Cancer Center, Yokohama, Japan; Department of Statistics (Y.C.), University of Pittsburgh, PA; and Department of Neurology (D.W.D.), Mayo Clinic, Scottsdale, AZ.

Neurology
|November 29, 2023
PubMed
概括

根据对真实世界患者数据的大规模分析,三,ergot和抗药在急性偏头痛治疗中表现出最高的有效性. 这些发现支持当前偏头痛管理治疗指南.

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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