通过MRI评估艾滋病毒感染患者的外周和中央嗅觉通路
A Ö Mete1, N Bayar Muluk2, M H Şahan3
1Infectious Diseases and Clinical Microbiology Department, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Clinical radiology
|November 29, 2023
概括
人类免疫缺陷病毒 (HIV) 感染与嗅球体积和嗅区域大小的减少有关,这表明潜在的嗅障碍. 疾病持续时间与这些变化无关.
科学领域:
- 神经成像是一种神经成像.
- 嗅觉神经科学是一种神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染可以影响中枢神经系统.
- 嗅觉功能障碍是艾滋病毒感染者的潜在症状.
- 头骨磁共振成像 (MRI) 是评估大脑结构的宝贵工具.
研究的目的:
- 通过使用头骨MRI,研究艾滋病毒感染患者的外周和中央嗅觉通路.
- 为了比较艾滋病毒感染者和对照组之间的嗅觉球泡 (OB) 体积和嗅觉硫 (OS) 深度.
- 探索嗅觉区域测量和艾滋病毒感染的临床参数之间的相关性.
主要方法:
- 分析了37名艾滋病毒感染成人和37名对照人群的头骨MRI扫描.
- 测量包括双边的OB体积,OS深度,岛屿,和桃体的区域.
- 记录了HIV组的临床数据,如疾病持续时间,HIVRNA和CD4计数.
主要成果:
- 与对照组相比,艾滋病毒感染的患者表现出明显较低的双边OB体积,岛屿,和桃体区域.
- 在艾滋病毒组中,在OB体积,OS深度和岛屿/体桃体区域之间观察到正相关性.
- 在临床参数 (年龄,性别,疾病持续时间,CD4计数,HIVRNA) 和嗅觉区域测量之间没有发现显著的相关性.
结论:
- 艾滋病毒感染患者的嗅觉区域减少表明与艾滋病毒相关的嗅觉障碍.
- 艾滋病毒的嗅觉障碍可能源于神经炎症,大脑缩或神经认知问题.
- 抗逆转录病毒疗法 (ART) 毒性的潜在作用需要进一步研究.
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