精神分裂症遗传风险对饮食障碍的影响 临床表现
Ruyue Zhang1,2, Ralf Kuja-Halkola1, Stina Borg1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Translational psychiatry
|November 29, 2023
概括
精神分裂症遗传责任影响饮食障碍 (ED),增加患重度抑郁症和药物滥用的风险. 多基因风险评分揭示了神经性厌食症和其他ED的独特临床表现.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 越来越多的证据将饮食障碍 (ED) 与精神分裂症联系在一起,这表明有共同的遗传因素.
- 在神经性厌食症 (AN) 患者中,精神分裂症的家族责任可能会影响不同的临床结果.
研究的目的:
- 研究精神分裂症多原风险评分 (PRS) 与ED患者的临床表现之间的关联.
- 评估精神分裂症遗传责任对ED症状,精神病并发症和整体健康负担的影响.
主要方法:
- 利用了厌食症神经遗传倡议 (ANGI) 和暴饮暴食遗传倡议 (BEGIN) 研究的数据.
- 使用瑞典国家患者登记册数据,研究了精神分裂PRS和ED临床特征,精神病并发症 (MDD,SUD) 和健康负担之间的关联.
- 分析了1973年以后出生的3573例ANGI病例和696例BEGIN病例的数据.
主要成果:
- 在ANGI病例中,更高的精神分裂症PRS与严重抑郁症 (MDD) 和物质使用障碍 (SUD) 的风险增加有关.
- 精神分裂症PRS与ANGI病例中的临床损伤得分降低有关.
- 在BEGIN病例中,较高的精神分裂症PRS与ED发病的早期年龄相关,ED症状得分较高,MDD和SUD风险增加.
- 对AN和其他ED (OED) 病例观察到类似的精神病并发症模式,但与ED相关的临床特征有所不同.
结论:
- 精神分裂症遗传责任影响精神病的并发症类似于神经性厌食症和其他饮食障碍.
- 基于精神分裂症PRS出现了与ED相关的临床特征的独特模式,需要进一步调查.
- 多基因风险评分提供了关于精神分裂症和饮食障碍之间的复杂相互作用的见解.
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