在sevoflurane诱导的全身麻醉中具有特征的动态功能连接性
Jingya Miao1,2, Mohamed Tantawi3, Mahdi Alizadeh4,3
1Department of Neurosurgery and Radiology, Thomas Jefferson University, Philadelphia, PA, USA. jingya.miao@jefferson.edu.
Scientific reports
|November 29, 2023
概括
总麻醉 (GA) 显著改变大脑动态,从波动的清醒状态转移到一个低功能连接 (FC) 状态. 动态FC分析揭示了麻醉期间明显的脑活动模式.
科学领域:
- 神经科学是一个神经科学.
- 麻醉学 麻醉学
- 医疗成像医学成像
背景情况:
- 众所周知,常常使用sevoflurane维持的全身麻醉 (GA) 会影响大脑功能连接 (FC).
- 之前的休息状态功能性MRI (rs-fMRI) 研究表明,与清醒相比,在GA期间抑制了FC,特别是在默认模式网络中.
- 之前的研究的局限性包括低于最佳的麻醉输送和短扫描持续时间,影响准确性和可靠性.
研究的目的:
- 为了研究在全身麻醉期间大脑的动态功能连接 (dFC) 变化,使用高精度的sevoflurane管理.
- 用rs-fMRI比较在清醒条件下的大脑状态与全身麻醉.
- 评估动态FC分析在评估麻醉剂对大脑活动的影响中的实用性.
主要方法:
- 在临床环境中,患者接受激光间歇性热疗法,以精确输送sevoflurane和15分钟的rs-fMRI获取.
- 利用组独立组分分析和滑动窗口方法,使用k-means集群来识别动态大脑状态.
- 在清醒状态和全身麻醉状态期间,对七名患者的静态和动态FC进行了分析.
主要成果:
- 确定了四种不同的动态大脑状态,其特征是不同的FC模式.
- 在整个rs-fMRI扫描中,全身麻醉状态主要与单个低FC脑状态有关.
- 清醒状态显示出三种不同的大脑状态之间的频繁过渡,包括在麻醉期间缺席的高度同步状态.
结论:
- 与清醒状态相比,全身麻醉会诱导大脑功能连接的显著动态变化.
- 动态FC分析提供了一种更敏感的方法来描述麻醉对大脑活动的影响.
- 这种方法为未来对麻醉药对神经网络影响的研究提供了基础.
相关概念视频
Stages of General Anesthesia
458
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
458
General Anesthesia: Overview
223
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
223
Inhalational Anesthetics: Overview
305
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
305


