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没有CDK4/6活动的Rb失活和外部信号的非正规途径协调细胞循环进入,没有CDK4/6活动

Mimi Zhang1, Sungsoo Kim1,2, Hee Won Yang3,4

  • 1Department of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA.

Nature communications
|November 29, 2023
PubMed
概括

哺乳动物细胞具有非正规的视网膜母细胞瘤 (Rb) 蛋白失活路径,绕过循环素依赖的激酶4和6 (CDK4/6). 这一途径与c-Myc和Cip/Kip水平一起,调节细胞增殖和静止.

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