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使用PET/CT通过准CXCR4来早期,非侵入性地检测辐射诱导的肺损伤

Jinli Pei¹, Kai Cheng², Tianxin Liu^1,3

¹Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.

European journal of nuclear medicine and molecular imaging

|November 29, 2023

概括

一种新型的标记物[18F]AlF-NOTA-QHY-04显示,它有望用于早期检测辐射诱导肺损伤 (RILI). 这种CXCR4向剂在临床前和临床研究中比[18F]FDG PET/CT更有效地识别RILI.

科学领域:

核医学就是核医学.
放射化学放射化学是指辐射化学.
在瘤学瘤学.

背景情况:

辐射诱导的肺损伤 (RILI) 是胸部放射治疗的一个重要并发症.
目前用于早期RILI检测的方法有限.
准C-X-C-化学因子受体-4型 (CXCR4) 为RILI成像提供了一个潜在的途径.

研究的目的:

为了合成和评估一种新型的正子发射断层扫描 (PET) 追踪器,AlF-NOTA-QHY-04,用于检测RILI.
评估追踪器能够比传统方法更早地识别RILI的能力.

主要方法:

为RILI.构建一个老鼠模型.
使用[18F]AlF-NOTA-QHY-04和[18F]FDG进行的PET/CT扫描在放射治疗后的老鼠中.
动态,阻断,自动放射和组织病理学研究.
在14名患有放射性肺炎的患者中进行临床评估.

主要成果:

[18F]AlF-NOTA-QHY-04在被辐射的老鼠肺部显示吸收增加,在RT后14天达到峰值.
[18F]FDG PET/CT在老鼠的早期阶段没有显著的RILI吸收.
自动放射学和免疫光学证实CXCR4表达在被辐射的肺组织中增加.
临床PET扫描显示,照射肺部的SUVmax显著更高,与RILI严重程度相关.

结论:

[18F]ALF-NOTA-QHY-04 PET/CT成像可以在老鼠模型中进行非侵入性和早期检测RILI.
追踪器的性能优于[18F]FDG PET/CT用于早期RILI检测.
临床研究证实了[18F]AlF-NOTA-QHY-04用于监测RILI的可行性,突出了其潜在的临床实用性.

关键词:

这是一种C-X-C-化学因子受体-4型.分子成像学分子成像学聚乙烯/聚乙烯/聚乙烯辐射引起的肺损伤.

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