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Updated: Jun 8, 2026

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在前脑器官的早期神经发育过程中的生殖系PTEN基因型依赖的表型差异

Shin Chung Kang1, Nicholas B Sarn1, Juan Venegas1

  • 1Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Molecular psychiatry
|November 29, 2023
PubMed
概括

PTEN突变是自闭症谱系障碍 (ASD) 关键风险基因. 这项研究表明,不同的PTEN突变会在不同阶段扰乱神经发育,影响神经元细胞命运和大脑发育,提供潜在的治疗点.

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