疫苗可预防的疾病导致肝移植接受者的不良结果
Aalam Sohal1, Isha Kohli2, Hunza Chaudhry3
1Department of Hepatology, Liver Institute Northwest, 3216 NE 45Th Pl, Suite 212, Seattle, WA, 98105, USA. asohal@liverinstitutenw.org.
Digestive diseases and sciences
|November 29, 2023
概括
疫苗可预防的疾病 (VPI) 影响了超过13%的肝移植住院病例,增加了死亡率和ICU入院. 提高这些高风险患者的疫苗接种率对于更好的结果至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 肝移植接受者 (LTR) 和慢性肝病 (CLD) 患者面临感染风险增加.
- 疫苗可预防的疾病 (VPI) 对这一脆弱人群构成重大威胁.
研究的目的:
- 确定住院LTR患者中VPI的发病率.
- 评估VPI对患者结局的影响,包括死亡率,ICU入院和急性损伤 (AKI).
主要方法:
- 使用国家住院样本 (NIS) 数据库从2016年到2020年.
- 使用ICD-10代码识别住院成人LTR.
- 分析了患者的人口统计,肝病病因,肝脏衰竭和结果,按VPI存在分层.
主要成果:
- 在170,650名住院的LTR中,13.5%患有VPI,主要是流感 (10.7%) 和肺炎球菌感染 (2.7%).
- VPI与较高的死亡率 (6.9%与1.6%),ICU入院率 (14.3%与3.4%) 和AKI (43.7%与37.35%) 显著相关.
结论:
- 超过13%的肝移植住院患者涉及VPI,导致患者的治疗结果较差.
- 研究结果强调需要调查疫苗接种障碍,并制定提高LTR疫苗接种率和免疫反应的策略.
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