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癌胚抗原 (CEA) 表达和EGFR突变在非小细胞肺癌中的相关性:元分析

Tian Gan¹, Wenting An², Yun Long¹

¹Department of Radiology, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, Hubei Province, China.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|November 29, 2023

概括

血清癌胚抗原 (CEA) 水平与非小细胞肺癌 (NSCLC) 的表皮生长因子受体 (EGFR) 突变有关. 升高的CEA可以预测EGFR突变,帮助NSCLC患者的治疗决策.

科学领域:

在瘤学瘤学.
分子诊断学分子诊断学
生物标志物研究生物标志物研究

背景情况:

非小细胞肺癌 (NSCLC) 是癌症死亡的主要原因.
表皮生长因子受体 (EGFR) 突变是NSCLC的关键治疗点.
预测EGFR突变状态的生物标志物对于个性化治疗策略至关重要.

研究的目的:

进行元分析,研究血清癌胚抗原 (CEA) 表达与NSCLC中的EGFR突变状态之间的关联.
评估CEA作为EGFR突变预测生物标志物在NSCLC患者中的潜力.

主要方法:

在PubMed,Cochrane,EMBASE和谷歌学者数据库中的系统文献搜索.
包括19项研究,包括4168名患者.
对几率比率 (OR) 的联合分析,以评估CEA表达和EGFR突变之间的相关性.

主要成果:

CEA阳性NSCLC瘤显示EGFR突变的发生率显著更高 (OR = 1.85,P < 0.00001).
这种关联在不同疾病阶段 (IIIB/IV和I-IIIA) 和腺癌 (ADC) 亚型中是一致的.
CEA表达与特定的EGFR突变相关,包括第19个外显子 (OR = 1.97) 和第21个外显子 (OR = 1.51).

结论:

血清CEA表达与NSCLC中的EGFR突变显著相关.
CEA水平可以作为EGFR突变状态的预测标志物,可能指导基因测试的需要.
监测CEA水平可能有助于对NSCLC患者的治疗规划和随访.

关键词:

在EGFR的突变.生物标志物生物标志物癌胚抗原是一种癌胚抗原.进行元分析分析.非小细胞肺癌的非小细胞肺癌.

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