基于联合喷雾干燥技术的高药载荷传统医学提取物的性能改善研究
Zhe Li1, Wanghai Peng1, Lin Zhu2
1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang, 330004, People's Republic of China.
AAPS PharmSciTech
|November 29, 2023
概括
通过联合喷雾干燥创建了修改后的伟迪黄 (LWDH) 颗粒. 多孔的核心外颗粒显著改善了粉末的流动性和紧缩性,使高药载荷的片剂成为可能.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
背景情况:
- 威迪黄 (LWDH) 粉末表现出较差的流动性和紧缩性,阻碍了直接紧缩 (DC) 片剂配方.
- 开发改性颗粒对于提高制药制造中的粉末性能至关重要.
研究的目的:
- 通过联合喷雾干燥,设计改造的伟迪黄 (LWDH) 颗粒,以提高流动性和紧性.
- 为了研究这些改性颗粒的制备机制和直接压缩 (DC) 特性.
- 从修改后的LWDH颗粒中准备和评估含量高的药物片.
主要方法:
- 联合喷雾干燥用于制备多孔颗粒 (Ps),核心外颗粒 (CPs) 和多孔核心外颗粒 (PCPs).
- 作为外材料,使用了聚烯利 (PVP K30) 和基基甲基纤维素 (HPMC E3).
- 碳酸和碳酸作为孔形成剂.
主要成果:
- 与Ps和CP相比,有孔的核心外颗粒 (PCP) 在DC特性中表现出最显著的改善.
- 贝结构增强了流动性,而多孔结构提供了更大的压缩空间.
- 联合喷雾干燥成功地创造了具有改善颗粒特性的复合结构.
结论:
- 联合喷雾干燥是一种有效的方法,用于开发具有优越流动性和紧缩性的修饰LWDH颗粒.
- 穿孔的核心外颗粒设计为改善直接紧缩性能提供了一个有希望的策略.
- 这种方法有助于生产具有更好的可制造性的高药载荷平板电脑.
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