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在患有状细胞贫血的儿童中,基于cystatin C的估计膜过率
Hakeem Edun Babatunde1, Afeez Oyesola Bello2, Muhammed A Nurudeen Adeboye3
1Department of Disease Control and Elimination, Medical Research Council Unit, The Gambia at London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P. O. Box 273, Banjul, The Gambia. edunhakim@gmail.com.
BMC nephrology
|November 29, 2023
概括
状细胞脏病在患有状细胞贫血 (SCA) 的儿童中很常见,许多儿童表现出超正常或降低的球过率 (GFR). 慢性病 (CKD) 的临床特征与SCA患者的GFR降低没有显著关联.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 儿科 儿科 儿科
- 血液学 血液学 血液学
背景情况:
- 状细胞疾病 (SCD) 是一种普遍存在的遗传性血液疾病,具有显著的脏并发症.
- 早期检测状细胞病对于改善患者的治疗结果至关重要.
- 这项研究重点关注患有状细胞贫血 (SCA) 的儿童的功能.
研究的目的:
- 为了比较患有SCA的儿童与健康对照的囊素C衍生的估计膜过率 (GFR).
- 为了将慢性病 (CKD) 的临床特征与SCA儿童的GFR降低相关联.
主要方法:
- 一项涉及86名SCA儿童和86名健康对照 (1-14岁) 的横截面研究.
- 用ELISA测量血清中细胞素C水平,通过Filler方程计算GFR.
- 收集了临床数据和人类测量测量.
主要成果:
- 与对照组相比,患有SCA的儿童的平均GFR显著不同 (116 ± 30相比106 ± 24毫升/分钟/1.73米2).
- 在SCA患者中,超正常GFR (>140mL/min/1.73m2) 的患病率为19.8%,降低GFR (<90mL/min/1.73m2) 的患病率为22.1%.
- 没有发现减少GFR与诊断时的年龄,输血,血压,细胞体积或等临床特征之间有显著的关联.
结论:
- 超常GFR在患有SCA的儿童中很普遍.
- 在这个队列中,CKD的临床指标与减少的GFR没有显著联系.
- 建议对患有SCA的儿童进行定期功能监测,以防止其进展为末期病 (ESKD).
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