环状晚期加多增强在非古典性心律失常性心肌病症中提供增量预后价值
Yuelong Yang1, Xiaoyu Wei2, Guanyu Lu3
1Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
概括
在非经典心律失常性心肌病 (ACM) 中,环状晚期加多增强 (LGE) 显著改善了心室失常 (VA) 的预测. 这一发现增强了2019年ARVC风险模型,以获得更好的患者结果.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 遗传学 遗传学 是一个
背景情况:
- 2019年心律失常性右室心肌病 (ARVC) 风险模型在预测非经典心律失常性心肌病 (ACM) 中心室心律失常 (VA) 方面存在局限性.
- 非经典ACM患者左心室中环状晚期加多增强 (LGE) 的预后意义目前尚不清楚.
研究的目的:
- 评估超出2019年ARVC风险模型的环状LGE的预后附加值,用于预测非经典ACM中的持续VA.
- 确定环状LGE是否可以改善该患者群体的风险分层.
主要方法:
- 在2011年1月至2022年1月期间连续接受心磁共振 (CMR) 的非经典ACM患者的回顾性分析.
- 使用考克斯回归,对LGE模式 (无,非环状,环状) 的分类和它们与持续VA相关性的评估.
- 计算曲线下的面积 (AUC),以量化环状LGE的增量预测值.
主要成果:
- 分析了73名患者的队列,41.1%的患者表现出环状LGE.
- 在多变量调整后,环状LGE与持续VA的更高风险 (调整后的危险比率:6.91,P=0.036) 独立相关.
- 将环状LGE纳入2019年ARVC风险模型显著提高了持续VA的预测能力 (AUC0.80对0.67,P=0.024).
结论:
- 环状LGE在非经典ACM患者中显示出独立的预后价值.
- 环状LGE的存在显著提高了2019年ARVC持续VA风险模型的预测准确度.
- 这一发现表明,环状LGE应在非经典ACM的风险分层中考虑.
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