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Updated: Jul 9, 2025

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
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揭示了骨髓瘤衍生的机密体在前转移性肺重塑中的作用

Sara F F Almeida1,2, Liliana Santos1,2, Gabriela Sampaio-Ribeiro2,3,4

  • 1Institute for Nuclear Sciences Applied to Health (ICNAS) and Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, 3000-548, Portugal.

Journal of experimental & clinical cancer research : CR
|November 30, 2023
PubMed
概括

这项研究揭示了骨肉瘤如何通过改变肺环境,促进炎症和纤维细胞激活来触发肺转移. EFEMP1被确定为一个关键的驱动因素和潜在的生物标志物,用于预测骨髓瘤患者的不良预后.

关键词:
在EFEMP1的基础上,EFEMP细胞外矩阵是细胞外矩阵.纤维细胞细胞.肺部转移 肺部转移中性粒细胞中性粒细胞.骨质肉瘤骨质肉瘤是什么前立腺瘤前的利基.

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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