在功能性消化不良症中,十二指肠生态系统,肠道微生物群和营养摄入量之间的关联
Sang Hoon Kim1, Yura Choi2, Jihong Oh2
1Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea.
Gut and liver
|November 30, 2023
概括
功能性消化不良 (FD) 涉及十二指肠炎和改变的肠道细菌,与饮食有关. 特定的十二指肠细菌和便Butyricicoccus可以作为FD诊断和监测的生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 功能性消化不良 (FD) 是一种具有多因素病理生理学的复杂综合征.
- 新出现的证据表明,十二指肠生态系统的改变是FD的核心.
- 这项研究调查了与FD十二指肠生态系统相关的胃肠道因素和生物标志物.
研究的目的:
- 为了确定与功能性消化不良相关的胃肠道因素和生物标志物.
- 探索十二指肠生态系统在FD病理生理学中的作用.
- 为了将饮食中的营养素,十二指肠免疫力和微生物组合与FD症状相关联.
主要方法:
- 一项涉及28名参与者的病例控制研究 (12名有FD,16名健康对照).
- 评估饮食营养素,症状严重程度,十二指肠粘膜免疫学和微生物组合 (口腔,十二指肠,便).
- 利用免疫组织化学,实时PCR,16SrRNA测序和网络分析进行综合数据分析.
主要成果:
- 患有FD的患者表现出十二指甲膜粘膜炎症和受损的紧结蛋白表达.
- 在FD中观察到十二指肠杆菌增加和便Butyricicoccus减少.
- 肠道微生物群的变化与症状严重程度相关;特定的微量营养素 (如素) 与改善的屏障功能有关.
结论:
- 突出了饮食,口腔/肠道微生物群,FD症状,十二指甲膜屏障功能和炎症之间的相互作用.
- 低度十二指管炎症和透性增加是潜在的FD指标.
- 十二指管粘膜评估和便Butyricicoccus丰度可能为FD诊断和监测提供客观的生物标志物.
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