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相关概念视频

PID Controller01:19

PID Controller

120
Proportional-Integral-Derivative (PID) controllers are widely used in various control systems to enhance stability and performance. In a thermostat, it adjusts heating or cooling based on the temperature difference between the actual and desired levels. They are often used in automotive speed systems, effectively managing sudden speed changes while maintaining a constant speed under varying conditions. On the other hand, PI controllers, commonly employed in voltage regulation, enhance stability...
120

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基于CFD的生物反应器模型,具有对溶解氧和pH的比例-整数-导数控制器功能.

Christopher L Oliveira1, Zoe Pace1,2, John A Thomas3

  • 1Bristol Myers Squibb Company, Global Product Development and Supply, Devens, Massachusetts, USA.

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概括

一个新的基于物理学的模型准确地预测了生物反应器的流体特性和控制器的反应. 这种模拟工具适用于工业研究和设计,优化细胞培养过程.

关键词:
在 CFD 交易中,我们可以看到 CFD.生物反应器的生物反应器运动学的动力学.过程控制过程控制运输现象 运输现象

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科学领域:

  • 生物化学工程 生物化学工程
  • 工艺系统工程 工艺系统工程
  • 计算流体动力学的流体动力学.

背景情况:

  • 精确预测流体动力学和质量转移对于优化生物反应器中细胞培养过程至关重要.
  • 整合过程和控制变量可以提高生物反应器的性能和稳定性.

研究的目的:

  • 开发和验证基于物理的模型,用于预测动生物反应器内的细胞培养液体特性.
  • 整合比例积分导数 (PID) 控制器逻辑,以直接合过程和控制变量.
  • 评估模型在预测稳定状态条件和对设定点变化的动态响应方面的准确性.

主要方法:

  • 为流体速度场和体积质量转移系数开发一个时间精确的计算模型.
  • 包括界面质量转移,物种混合和水性化学反应动态.
  • 嵌入式PID控制器逻辑用于实时模拟系统控制.

主要成果:

  • 该模型成功地预测了流体速度,质量转移,混合和反应动力学.
  • 在模型预测和实验生物反应器数据之间证明了令人满意的一致性.
  • 经过验证的稳定状态运行条件和对设定点调整的动态响应.

结论:

  • 基于物理的模型提供了一个可靠的工具来模拟生物反应器的性能.
  • 集成的控制器逻辑能够准确预测合的过程和控制动态.
  • 模拟效率适用于工业研究和设计应用.