自闭症谱系障碍中的甲尿症:一篇综述
Geir Bjørklund1, Yuliya Semenova2, Afaf El-Ansary3
1Department of Research, Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.
Current medicinal chemistry
|November 30, 2023
概括
暴露于可能与儿童的自闭症谱系障碍 (ASD) 有关. 在ASD儿童中观察到尿中氨酸的升高,如前氨酸 (prcP) 和氨酸 (cP),这表明毒性的潜在生物标志物.
科学领域:
- 环境健康 环境健康
- 神经发育障碍 神经发育障碍
- 毒理学 毒理学 毒理学
背景情况:
- 自闭症谱系障碍 (ASD) 患病率上升,环境因素对其病因有所贡献.
- 在ASD研究中,了解环境毒素 (如) 的作用至关重要.
- 现有研究表明,暴露与ASD特征之间存在潜在联系.
研究的目的:
- 进行范围审查,评估当前有关ASD儿童暴露的信息.
- 确定有关在ASD病因学中的作用的知识差距.
- 探索尿道氨酸作为ASD中暴露的生物标志物的潜力.
主要方法:
- 使用范围审查方法来综合现有文献.
- 系统地分析了对ASD儿童的暴露和尿孔啡水平的数据.
- 与对照组对发现的比较是审查的一个关键方面.
主要成果:
- 与对照人群相比,在患有自闭症的儿童中观察到尿液中高度的先前甲 (prcP),甲 (cP) 和五碳氧甲 (5cxP).
- 这些升高的氨酸是暴露于的迹象.
- 增加prcP,cP和5cxP的特定模式可以作为ASD中暴露的潜在生物标志物.
结论:
- 这些发现表明,通过特定的尿道氨酸表明的暴露与ASD之间存在相关性.
- 尿道氨酸 (prcP,cP,5cxP) 的确定的模式显示,作为ASD中暴露的生物标志物具有前途.
- 存在显著的数据差距,特别是在未来研究中需要性别和年龄匹配的对照组.
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