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细菌纤维素-单氨酸伤口敷料的辐射处理:物理化学效应,功能分析和杀菌
Charito Tranquilan-Aranilla1, Jeric Flores1,2, Alvin Kier Gallardo1
1Department of Science and Technology, Philippine Nuclear Research Institute, Quezon, Philippines.
Journal of biomaterials applications
|November 30, 2023
概括
细菌纤维素-单氨酸伤口敷料的玛和电子束辐射灭菌显示了轻微的结构变化,但保持了有益的伤口愈合特性. 15kGy剂量适用于杀菌,确保产品的完整性和功能.
科学领域:
- 生物材料科学 生物材料科学
- 辐射化学 辐射化学
- 医疗器械灭菌 医疗器械灭菌
背景情况:
- 细菌纤维素-单氨酸复合材料是有前途的伤口包裹材料.
- 绝育方法必须保持先进伤口带的功能性质.
- 电离辐射是医疗器械常见的灭菌技术.
研究的目的:
- 评估玛和电子束辐射对细菌纤维素-单氨酸伤口敷料的影响.
- 为了确定电离辐射是否适用于这些敷料的灭菌.
- 根据ISO 11137-2:2016的标准,验证15kGy绝育剂量的疗效.
主要方法:
- 里埃变换红外光谱 (FT-IR) 用于化学结构分析.
- 拉伸测试用于机械强度评估.
- 热重力测量分析 (TGA) 用于热降解.
- 扫描电子显微镜 (SEM) 和X射线衍射 (XRD) 检测形态和结构变化.
- 膨胀测试,排泄物吸收,以及对功能性质的水蒸气传递率测量.
主要成果:
- 通过FT-IR观察到辐射诱导的氧化.
- 拉伸强度和热降解温度的降低表明纤维素网的降解.
- SEM揭示了一种不那么密集的纳米结构,而XRD显示了晶格平面的变化.
- 功能性质,包括排泄物吸收和水蒸气传递,保持或改善,特别是在15-25kGy.
- 15kGy的绝育剂量得到了验证.
结论:
- 电离辐射会对细菌纤维素-单氨酸伤口造成轻微的结构和机械变化.
- 这些变化并没有显著地影响伤口愈合的基本功能性质.
- 电离辐射,特别是15kGy,是这种伤口包装产品的合适和验证的灭菌方法.
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