评价胆囊收缩性和多普勒检测结果在患有刺激性肠综合征的患者;一个病例对照研究
Samin Alihosseini1, Farzaneh Khodaei1, Mehran Jaberinezhad2
1Medical Radiation Sciences Research Group, Tabriz University of Medical Sciences, Tabriz, The Islamic Republic of Iran.
Scandinavian journal of gastroenterology
|November 30, 2023
概括
与健康个体相比,刺激性肠综合征 (IBS) 患者表现出改变的胆囊排空和血液动力学反应. 这项研究利用多普勒超声波来调查这些差异,表明胆囊功能与IBS病理生理学之间的潜在联系.
科学领域:
- 胃肠病学 胃肠病学
- 医疗成像医学成像
- 生理学 生理学 生理学
背景情况:
- 刺激性肠综合征 (IBS) 是一种普遍存在的功能性胃肠疾病,其特点是腹痛,改变肠道习惯和胀气.
- 胆囊功能障碍,可能与胆囊托基宁的释放有关,被假设与IBS有关.
- 多普勒超声波是评估胆囊功能和血液动力学参数的宝贵工具.
研究的目的:
- 与健康对照组相比,评估便秘主导性IBS (C-IBS) 患者的胆囊功能和相关的血液动力学参数.
- 评估胆囊体积的变化,胆囊壁厚度和动脉阻力指数在饭前和饭后使用超声波.
主要方法:
- 一项涉及18名C-IBS患者和16名健康志愿者的病例控制研究.
- 进行了超声波测量胆囊禁食和食后体积,胆囊排空分数 (EF),以及囊性动脉和上层介质动脉 (SMA) 的阻力指数 (RI).
- 统计分析包括学生t测试和配对t测试,以比较组和餐前与餐后数据.
主要成果:
- 与对照组相比,IBS患者的胆囊排空分数显著增加 (p=0.009).
- 在IBS患者和对照人群 (p=0.016) 之间,在禁食SMA RI中观察到统计学上显著的差异,IBS患者的RI较低.
- 在两组之间,SMA RI或囊性动脉 RI的饭后变化没有发现显著差异.
结论:
- IBS患者表现出明显的胆囊排空特征和血液动力学特征,特别是更高的EF和更低的禁食SMA RI.
- 这些发现表明胆囊功能障碍在IBS病理生理学中的潜在作用.
- 需要对更大的队列和各种IBS亚型进行进一步的研究,以阐明这些关联.
相关概念视频
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
165
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
165
Irritable Bowel Syndrome I: Introduction
280
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
280
Assessment of the Gastrointestinal System I: Subjective Data
200
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
200
Chronic Bowel Disorders: Introduction
456
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
456
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
86
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
86
Drugs for Treatment of Diarrhea-Predominant IBS
182
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
182


