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在水性介质中用氨基酸修饰的多胺-胺-氨酸的形状变化及其对细胞相容性和血液溶解反应的影响

Arianne Maine¹, Laura Tamayo¹, Ángel Leiva²

¹Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Casilla 653, Ñuñoa, Santiago 7800003,Chile.

ACS applied bio materials

|November 30, 2023

概括

用氨基酸 (PSMA-Aa) 修饰的多烯化-高乙烯 (PSMA) 显示了影响表面活性和生物反应的构造变化. 了解这些变化是生物材料应用的关键.

科学领域:

聚合物科学聚合物科学
生物材料科学生物材料科学
表面化学表面化学

背景情况:

聚乙-乙烯 (PSMA) 是一种多功能聚合物骨干.
用氨基酸 (PSMA-Aa) 进行修改可以改变聚合物特性.
了解水溶液中的多电解质行为对于生物材料开发至关重要.

研究的目的:

为了研究氨基酸改性PSMA (PSMA-Aa) 在水性介质中的构造变化.
为了将这些形状变化与表面活动和生物反应相关联.
评估PSMA-Aa作为生物材料的潜力.

主要方法:

粘度测量以确定聚合物形状.
测量表面张力以评估表面活动.
分子动力学模拟和溶剂可访问的表面积研究.
血液溶解活性测定和细胞相容性测试.

主要成果:

随着盐度的增加,PSMA-Aa的特定粘度下降,这表明其结构更加紧.
用l-phenylalanine修改的PSMA表现出增强的表面活性和血液溶解活性.
形状变化取决于pH值,pH值为4.0的结构是紧的,pH值为7.0的结构是延伸的.
没有观察到PSMA-Aa的显著细胞毒性作用,但在pH值7.0和高盐度下观察到线粒体膜潜在损失.

结论:

PSMA-Aa的形状变化显著影响其表面活性和生物相互作用.
特别是与l-phenylalanine,PSMA-Aa的表面活性特性与溶血活性相关.
作为生物材料,PSMA-Aa表现有前途,但它们的生物效应需要根据结构状况仔细考虑.

关键词:

氨基酸氨基酸是一种氨基酸.细胞相容性细胞相容性血液溶解活动的血液溶解活动.马列酸无水化物马列酸无水化物多元电解质的电解质.

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