通过顺序化和小分子插入来修改一个常见的β-diketiminate NacNac框架
Jennifer R Lynch1, Alan R Kennedy1, Jim Barker2
1Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK.
Chemistry (Weinheim an der Bergstrasse, Germany)
|November 30, 2023
概括
研究人员通过功能化NacNac骨干开发了新的三脚式β-diketiminate (BDI) 或NacNac连接体. 这些新配体提供多种协调位点 (N,N,N,O; N,N,N,S; N,N,N,N,N) 进行先进的合成和催化.
科学领域:
- 协调化学 协调化学
- 有机合成 有机合成
- 催化剂是一种催化剂.
背景情况:
- β-二基胺酸 (BDI) 或NacNac配体在合成和催化中广泛使用.
- 在此之前,NacNac骨干的γ-C-H单元被认为是无反应的.
- 最近的发现揭示了γ-C-H单元与电友的反应性.
研究的目的:
- 为了利用 NacNac 骨干的反应性来创建新的联体架构.
- 为了合成常见的NacNac连接体的三脚修饰.
- 探索这些新的连接体变体的协调化学.
主要方法:
- NacNacH (Me,Dipp) 的 γ-C-H 单位的脱,形成 NacNacLi.
- NacNacLi与电友的反应:异酸盐,异酸盐和碳二胺.
- 合成的三脚式NacNac变体及其化衍生物的晶体学表征.
主要成果:
- 一系列具有N,N,N,O;N,N,N,S;或N,N,N,N,N的三脚NacNac连接物被成功合成.
- 通过X射线结晶学证实了多个新的联结体结构.
- 通过它们的化中间体的晶体结构,阐明了新型三脚的明显结合模式.
结论:
- NacNac带的 γ-C-H 单元可以优势地功能化,以创建多功能三脚带.
- 这些新的配体为催化应用提供可调节的协调环境.
- 这项研究扩大了NacNac连接体设计和在协调化学中的应用范围.
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