后皮层缩患者的社会认知和行为变化
Marie-Anne St-Georges1, Linshan Wang2, Marianne Chapleau3
1Douglas Research Centre, Montréal, QC, H4H 1R3, Canada.
Journal of neurology
|November 30, 2023
概括
早期后皮层缩 (PCA) 涉及到诸如焦虑和抑郁等行为症状,与最初的看法相反. 社会认知在很大程度上被保留,在视角采取方面有轻微的障碍.
科学领域:
- 神经科学是一个神经科学.
- 行为神经学 行为神经学
- 老年学是指老年学的学科.
背景情况:
- 后皮层缩 (PCA) 是一种罕见的神经退行综合征,主要导致视觉和视觉空间缺陷.
- 目前的诊断标准表明,在PCA早期阶段的行为和个性相对较少.
- 有限的研究已经探索了早期PCA的行为和社会认知概况.
研究的目的:
- 调查和描述PCA早期阶段的行为症状和社会认知.
- 将PCA患者与健康对照者 (HC) 和其他阿尔茨海默病 (AD) 变体进行比较,包括典型的AD (tAD) 和逻辑变体初级渐进性失语症 (lvPPA).
- 改进对PCA非视觉症状的理解,以改善诊断和干预.
主要方法:
- 利用了来自国家阿尔茨海默氏症协调中心 (NACC) 数据集的数据.
- 包括157名早期PCA患者,352名HC患者,202名tAD患者和177名lvPPA患者.
- 雇佣的临床医生评级,告知者和临床医生填写的问卷,以及面对患者的行为和社会认知评估测试.
主要成果:
- 患有PCA的患者经常表现出焦虑,抑郁,冷漠和易怒.
- 临床医生在测试期间注意到无组织和反应性行为,但不是不敏感.
- 告密者报告显示,PCA患者对非奖励,新奇和惩罚刺激的抑制和焦虑增加.
- 社会规范知识和同理心通常保持不变,在视角和社会情感敏感性方面存在较小的缺陷.
结论:
- 早期的PCA呈现出显著的行为症状,挑战了保留个性的概念.
- 社会认知表现出相对的保存,在特定领域如视角采用等方面有微妙的损害.
- 这些发现提高了对PCA复杂临床表现的理解,并为诊断和治疗策略提供了信息.
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