年龄和手术前的HbA1c水平会影响活体脏捐赠者的功能补偿
Taihei Ito1, Takashi Kenmochi2, Kei Kurihara2
1Department of Transplantation and Regenerative Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo Kutsukake-Cho, Toyoake, Aichi, 470-1192, Japan. i-taihei@fujita-hu.ac.jp.
International urology and nephrology
|November 30, 2023
概括
捐赠者的年龄和HbA1c影响活体捐赠后功能恢复. 年长的女性捐赠者和HbA1c较高的男性捐赠者在腎切除术后六个月表现出更差的功能补偿.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植手术 移植手术
- 公共卫生 公共卫生
背景情况:
- 活体捐赠者的移植在日本很普遍,约90%的手术涉及活体捐赠者.
- 确保捐赠者的安全和长期的功能对于活着的脏捐赠者来说至关重要.
研究的目的:
- 确定影响活体脏捐赠者脏切除术后恢复功能的因素.
- 分析捐赠者特征对捐赠后功能的影响.
主要方法:
- 从2012年到2021年,对120名活着的脏捐赠者进行了回顾性队列研究.
- 用单变量和多变量线性回归分析来评估影响功能的捐赠因素.
- 经切除术后六个月估计的淋巴膜过率 (eGFR) 是主要结果指标.
主要成果:
- 捐赠者的年龄,手术前的eGFR和血红蛋白A1c (HbA1c) 是六个月后eGFR的独立风险因素.
- 在女性捐赠者中,eGFR恶化随着年龄的增长而变得更加明显,而在男性捐赠者中,HbA1c的升高.
- 较高的供体年龄和HbA1c水平与腎切除术后增强的eGFR恶化有关.
结论:
- 晚年捐赠者年龄,特别是在女性中,以及高的手术前HbA1c,特别是在男性中,对活体捐赠者切除术后的功能补偿产生负面影响.
- 这些发现突显出需要仔细选择和监测捐赠者,以保持脏健康.
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