对于雪松花粉症的语言下免疫疗法可能会引发异氨酸性食道炎
Toshio Yamagata1, Hirokazu Saito2, Atsushi Fujimoto1
1Department of Gastroenterology, Kumamoto City Hospital, 4-1-60, Higashimachi, Higashi-Ku, Kumamoto City, Kumamoto, 862-8505, Japan.
Clinical journal of gastroenterology
|November 30, 2023
概括
语言下免疫疗法 (SLIT) 可以引发异性食道炎 (EoE),这是一个罕见的副作用. 切换到 SLIT 的唾液方法减少了树花粉症和多种过敏症患者的症状.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 舌下免疫疗法 (SLIT) 是一种常见的治疗雪松花粉症的方法.
- 性食道炎 (EoE) 是一种已知的,虽然不太常见的,SLIT的不良影响.
- 患有多种过敏疾病的患者可能面临更高的风险.
研究的目的:
- 报告SLIT诱导的EoE病例,该病例发生在患有雪松花粉症和其他过敏症的患者身上.
- 突出承认SLIT触发的EoE的重要性.
- 建议SLIT触发的EoE的管理策略.
主要方法:
- 一个26岁的男性患有雪松花粉症,依赖小麦的运动诱导过敏症和食物过敏症的案例研究.
- 在开始SLIT后,喉发,消化不良,胃灼热和胸痛的临床表现.
- 诊断评估包括实验室检测,食道胃二透镜和食道活检.
主要成果:
- 患者在开始SLIT后8天出现了与EoE一致的症状.
- 在血液和食道活检中发现了高氨基酸.
- 食道胃管腺镜检查显示了整个食道的线性痕.
- 切换到 SLIT 的唾液方法导致症状减少.
结论:
- SLIT触发的EoE是雪松花粉症患者的潜在不良事件,特别是那些患有多种过敏症的患者.
- 早期识别和管理,包括切换到唾液方法,可以有效.
- 在EoE的情况下,吐方法可能是停止SLIT的可行替代方案.
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