移植患者患有持续性副甲状腺功能障碍症的高血症的长期影响
Juan Carlos Ramirez-Sandoval1, Lluvia Marino2, Gabriel Cojuc-Konigsberg2
1Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, colonia Sección XVI, 14080, Mexico City, CDMX, Mexico. carlos.ramirezs@incmnsz.mx.
Journal of nephrology
|November 30, 2023
概括
持续的轻度高血症在移植后很常见,但不会显著增加不良的移植结果. 这种情况与特定的代谢变化有关,类似于轻度原发性甲状腺功能障碍症.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 移植 移植 移植 移植
背景情况:
- 过血症在患有副甲状腺功能障碍的移植患者中很常见.
- 超血症对移植功能的长期影响仍然不确定.
研究的目的:
- 调查移植受体中与持续高血症相关的不良移植结果.
- 分析移植受体患有持续高血症的代谢障碍.
主要方法:
- 对385名脏移植接受者的前性队列研究.
- 持续性高血症被定义为自由>5.2 mg/dL在≥80%的测量中,与高度完整的副甲状腺激素 (> 30 pg/mL) 相比.
- 监测无症状轻度高血症,除非出现并发症.
主要成果:
- 62%的接受者在中位数4年的随访期间患有持续性高血症.
- 与非高血接受者相比,在移植功能障碍,尿病,沉积或骨折方面没有显著差异.
- 超血患者的尿含量较高,纤维细胞生长因子23完好,25-氧维生素D水平较低.
结论:
- 长期持久的轻度高血是移植后经常出现的情况.
- 代谢特征类似于轻度的原发性甲状腺功能增强症,但具有不良移植结果的低风险.
- 移植前完整的副甲状腺激素<300 pg/mL与移植后高热血症的风险降低有关.
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