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基于单细胞RNA测序的基因调控网络重建算法的审查

Hyeonkyu Kim1, Hwisoo Choi1, Daewon Lee2

  • 1School of Systems Biomedical Science, Soongsil University, 369 Sangdo-Ro, Dongjak-Gu, Seoul, 06978, Republic of Korea.

Genes & genomics
|November 30, 2023
PubMed
概括

单细胞RNA测序 (scRNA-seq) 通过捕捉动态细胞变化来推进基因调控网络 (GRN) 的重建. 选择合适的GRN工具取决于是否需要用于特定研究目标的细胞轨迹分析.

关键词:
基因监管网络是基因监管网络.逆向工程是一种逆向工程.一个单细胞RNA测序.轨迹推断的推理方法

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RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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