长期接受氧气治疗的患者2年死亡率的预测因素:一项前性观察性研究
Hiroki Annaka1, Tomonori Nomura1, Hiroshi Moriyama2
1Department of Occupational Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, Japan.
Journal of palliative medicine
|November 30, 2023
概括
长期接受氧气治疗的患者的死亡率预测因素包括手握强度,呼吸障碍 (修改的英国医学研究理事会规模),日常活动 (巴特尔指数) 和认知功能 (蒙特利尔认知评估). 这些因素可以识别有风险的个人.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 老年学是一门学科.
- 临床流行病学 临床流行病学
背景情况:
- 长期接受氧气治疗 (LTOT) 的患者面临着渐进的呼吸功能障碍和高死亡率.
- 在这个脆弱人群中,死亡率的预测因素在很大程度上仍未被定义.
- 确定这些预测因素对于有针对性的干预和改善患者结果至关重要.
研究的目的:
- 在接受长期氧气治疗的患者中,前性地确定两年死亡率的关键预测因素.
- 分析基线临床和功能评估与随后死亡率之间的关联.
- 提供LTOT患者风险分层的证据.
主要方法:
- 一项为期两年的前性观察性研究,涉及96名接受LTOT的患者.
- 收集的基线数据包括更新的查尔森并发症指数,BMI,手握强度,修改的英国医学研究理事会规模 (mMRC),巴特尔指数 (BI) 和蒙特利尔认知评估 (MoCA).
- 考克斯的比例危险模型被用来估计死亡率的预测因素.
主要成果:
- 在83名随访患者中,有30人 (36%) 在两年内死亡.
- 确定的死亡率的重要预测因素是手握强度降低 (HR:0.89),mMRC得分增加 (HR:1.96),BI得分降低 (HR:0.95) 和MoCA得分降低 (HR:2.17).
- 这些发现强调了身体功能和认知状态的预后价值.
结论:
- 手握强度,呼吸障碍严重程度,日常生活活动和认知功能是长期接受氧气治疗的患者两年死亡率的重要预测因素.
- 这些因素可以帮助识别高风险个体,以便更密切地监测和量身定制的管理策略.
- 进一步的研究应该探索针对这些可修改的预测因素的干预措施.
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