乳腺癌中TUBA1C的表达升高预示着预后不佳
Yi Zhao1, Wenwen Wang1,2, Jinming Li1,3
1Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, QingHai, China.
PloS one
|November 30, 2023
概括
乳腺癌中高表达的α-1C-tubulin (TUBA1C) 与较差的生存结果有关. TUBA1C作为乳腺癌预后的独立风险因素.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 阿尔法-1C-氨酸 (TUBA1C) 是阿尔法-氨酸家族的成员,具有作为癌症生物标志物的潜力.
- 之前的研究表明,TUBA1C可能与各种癌症有关,因此需要对特定恶性瘤进行进一步的研究.
研究的目的:
- 使用癌症基因组图谱 (TCGA) 数据全面评估TUBA1C在乳腺癌中的预后价值.
- 确定TUBA1C基因表达与乳腺癌患者的临床特征之间的相关性.
主要方法:
- 利用TCGA数据进行TUBA1C.的基因表达分析.
- 采用了统计测试,包括威尔科克森签名等级,克鲁斯卡尔-瓦利斯,后勤回归和考克斯回归分析.
- 进行了卡普兰-梅尔分析和基因组丰富分析 (GSEA),以评估生存影响和途径丰富.
主要成果:
- 在乳腺癌中,高TUBA1C表达与生存时间,生存状态和瘤大小有显著的相关性.
- 升高的TUBA1C水平预测了较差的整体存活率 (OS),无复发存活率 (RFS) 和远程转移无存活率 (DMFS).
- 在单变量和多变量分析中,TUBA1C被确定为OS的独立预后因素.
结论:
- 图巴1C的高传递 RNA (mRNA) 表达是乳腺癌预后不佳的独立风险因素.
- TUBA1C表达影响关键的生物通路,包括细胞周期,P53信号传递和与癌症相关的通路.
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