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推进性细胞进入通过重塑细胞突触来使病原体从免疫降解中转移

Zihan Zhang¹, Thomas K Gaetjens², Jin Ou¹

¹Department of Chemistry, Indiana University, Bloomington, IN 47405-7102.

Proceedings of the National Academy of Sciences of the United States of America

|November 30, 2023

概括

来自积极移动的病原体的物理力量,而不仅仅是毒性因素,可以帮助它们逃避免疫降解. 这是通过破坏正常的细胞过程而发生的,防止病原体的破坏.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
病原体与宿主之间的相互作用

背景情况:

消化细胞对清除病原体和保持组织健康至关重要.
病原体经常使用毒性因子,以逃脱phagolysosomes内部的降解.
物理力量在病原体逃避中的作用尚未得到充分理解.

研究的目的:

调查病原体进入过程中的物理力是否会导致免疫逃避.
为了区分物理力量与毒性因子对法戈利索姆成熟的影响.
探索以武力为媒介的逃避机制的普遍性.

主要方法:

由于其活跃的入侵机制,利用*Toxoplasma gondii*作为一个模型寄生虫.
采用磁力来模拟无活化寄生虫的推进性进入巨细胞.
进行了酵母细胞和opsonized珠子的实验,以测试一般性.
进行计算机模拟来分析细胞突触中的受体-酶相互作用.

主要成果:

推进力阻碍受体激活,因为它阻止了细胞突触中的酸酶的空间分离.
通过诱导力进入的非活化寄生虫被封闭在未成熟的真空中,模仿活的寄生虫通路.
这种依赖于力的逃避机制在使用非寄生性颗粒时得到证实,这表明它具有广泛的适用性.

结论:

进入过程中移动病原体所施加的物理力量可以独立地触发免疫逃避.
这种机制通过改变细胞突触动力学来规避细胞体退化.
揭示了一种新的病原体免疫逃避策略,独立于传统的毒性因素.

关键词:

免疫逃避免疫逃避磁性操纵是一种磁性操纵.细胞突触 (phagocytic synapse) 是一种细胞突触,发生在细胞内.发酵体成熟的过程推进力是一种推进力.

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