高多基因风险评分是与结直肠癌相关的风险因素,基于英国生物银行的数据
Mei Yang1, Vagheesh M Narasimhan2,3, F Benjamin Zhan1,4
1Department of Geography and Environmental Studies, Texas State University, San Marcos, Texas, United States of America.
PloS one
|November 30, 2023
概括
高多基因风险分数 (PRS) 是结直肠癌 (CRC) 的重要风险因素,即使考虑到家族病史. 这种遗传倾向,以及男性性别和失业等因素,增加了CRC风险.
科学领域:
- 遗传学和流行病学
- 癌症研究 癌症研究
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因,需要确定关键风险因素.
- 了解遗传倾向和其他促成因素对于制定有效的CRC预防和管理策略至关重要.
研究的目的:
- 调查结直肠癌 (CRC),多基因风险评分 (PRS) 和其他人口和生活方式因素之间的关联.
- 在英国大型生物库队列中确定CRC的重大风险因素,包括按年龄分层的分析.
主要方法:
- 使用来自英国生物库的2,585例CRC病例和9,362例对照数据,采用了病例控制研究设计.
- 多基因风险评分 (PRS) 根据140个单核酸多态基因对11,947个个体进行了计算.
- 进行了后勤回归分析,以评估PRS,其他因素和CRC风险与年龄分层之间的关联.
主要成果:
- 鉴定了五种CRC的重大风险因素:高PRS (aOR:2.70),男性性别 (aOR:1.52),失业 (aOR:1.47),家族CRC病史 (aOR: 1.44) 和年龄 (aOR: 1.01).
- 这五个因素对于50岁及以上的人来说仍然很重要.
- 在年轻人 (50岁以下) 中,只有高PRS (aOR:2.87) 和家族CRC病史 (aOR:1.73) 是显著的风险因素.
结论:
- 高多基因风险评分 (PRS) 是结直肠癌 (CRC) 的重要,独立的风险因素,即使考虑到家族病史.
- 遗传倾向在不同年龄段的CRC发展中起着重要作用.
- 需要对更大,更多样化的群体进行进一步的研究,以验证这些发现并探索潜在的机制.
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