一项试点研究,以评估远程监控高强度间歇训练计划的可行性,以便在全源造血干细胞移植之前进行高强度间歇训练
Ashley L Artese1,2, Hilary M Winthrop3, Lauren Bohannon3
1Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, United States of America.
PloS one
|November 30, 2023
概括
血造前干细胞移植 (HCT) 高强度间歇训练 (HIIT) 是可行的,可以改善心肺健康和身体功能. 这种基于家庭的,远程监控的计划为接受HCT的患者提供了显著的好处.
科学领域:
- 运动生理学 运动生理学
- 移植医学 移植医学
- 心血管健康 呼吸系统健康
背景情况:
- 全基性造血干细胞移植 (HCT) 具有治愈潜力,但可能导致身体功能和心肺呼吸能力降低.
- 高强度间歇训练 (HIIT) 是一个有前途的干预措施,可以提高HCT前的健康状况.
研究的目的:
- 评估在异性HCT之前在家进行远程监控HIIT计划的可行性.
- 从基线到HCT,评估心肺健康和身体功能的变化.
主要方法:
- 一个单臂试点研究,涉及预定接受异构HCT的患者.
- 参与者每周完成三次30分钟的家庭 HIIT 训练,通过 Apple Watch 监控.
- 通过保留和坚持来评估可行性;使用对联t-test分析的适应性变化.
主要成果:
- 观察到高坚持率 (100%的会议坚持率中位数) 和保留率 (69.2%).
- 在VO2峰值 (p<0.001),30秒坐到站,以及短物理性能电池 (SPPB) 得分上显著改善.
- 关键功能指标的改善超过了临床上重要的最小差异.
结论:
- 在HCT前的家庭HIIT计划是可行的,并且耐受良好.
- 这种干预表明,它有可能改善HCT候选人的心肺呼吸能力和身体功能.
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