停止压力内皮质层气溶化疗 (PIPAC) 的原因:一项回顾性研究,以改善未来的患者选择
Anne-Cécile Ezanno1, Brice Malgras1,2, Pierre-Louis Conan3
1Department of Digestive Surgery, Begin Military Teaching Hospital, Saint Mandé, France.
PloS one
|November 30, 2023
概括
压缩性腹腔内气溶化疗 (PIPAC) 经常被提前停止. 疾病的进展是主要原因,但建议在未经化疗治疗的患有炎的患者中避免单独使用PIPAC.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 腹转移 (PM) 对患者的预后和生活质量产生负面影响.
- 压力内气溶化疗 (PIPAC) 是一种新的PM治疗方法.
- 最佳的PIPAC治疗通常包括至少三个程序,但许多患者没有完成这个过程.
研究的目的:
- 为了确定PIPAC过早停止的原因 (经过一两个程序后).
- 建立可能成为PIPAC全方位治疗方案的不良候选人的患者的临床概况.
主要方法:
- 追溯的,多中心的队列研究.
- 包括所有在法国三个专家中心接受PIPAC的患者 (2015-2021年).
- 分析了89名患者的268个PIPAC程序,以确定停止治疗的原因.
主要成果:
- 48.3%的患者接受了不到三次PIPAC手术.
- 疾病进展是停止PIPAC的主要原因 (55.8%).
- 其他原因包括无法进入腹腔,转换为手术,不良事件,患者的愿望和死亡.
- 接受不到三种PIPACs的患者不太可能先前接受化疗或双模治疗,并且更有可能患上,特别是癌性.
结论:
- 疾病进展是停止PIPAC治疗的最常见原因.
- 患有炎的患者,尤其是癌性炎患者,以及那些从未接受过化疗的患者可能是PIPAC的较差候选人.
- 应考虑避免PIPAC作为化学疗法先前未经过治疗的炎患者的独立治疗.
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