当NSCLC患者与EGFR-TKI进展缓慢时添加apatinib:一个前性的单臂研究
Minghui Liu1, Xin Li1, Hongbing Zhang1
1Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Cancer medicine
|November 30, 2023
概括
将阿帕蒂尼布添加到表皮生长因子受体氨酸激酶抑制剂 (EGFR-TKI) 中,可以克服在NSCLC治疗中获得的耐药性. 这种组合疗法改善了无进展的生存率,并且是一种可行的选择,具有可管理的副作用.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 遗传学 遗传学 是一个
背景情况:
- 对表皮生长因子受体氨酸激酶抑制剂 (EGFR-TKI) 获得的耐药性是非小细胞肺癌 (NSCLC) 治疗的一个重大挑战.
- 开发克服这种抗性的策略对于改善患者的治疗结果至关重要.
研究的目的:
- 评估添加阿帕蒂尼布到第一代EGFR-TKI在获得耐药性NSCLC患者中的疗效和安全性.
- 探索循环瘤DNA (ctDNA) 作为治疗反应生物标志物的潜力.
主要方法:
- 一项临床试验招募了12名第一代EGFR-TKI治疗进展缓慢的患者,将阿帕蒂尼布添加到他们的治疗方案中.
- 在七名患者中评估了疗效和不良事件. 分析了无进展生存期 (PFS),包括PFS2和总PFS (PFS1 + PFS2).
- 研究了ctDNA清除和PFS之间的相关性.
主要成果:
- 组合治疗的PFS2中位数为8.2个月,总PFS中位数为20.9个月.
- 与未清除ctDNA的患者 (7.1个月) 相比,获得ctDNA清除的患者的PFS中位数明显更长 (8.4个月) (p=0.0082).
- 与阿帕蒂尼布相关的所有不良事件都是可控的.
结论:
- 将阿帕蒂尼布添加到第一代EGFR-TKI治疗中,对于患有获得性耐药性的NSCLC患者来说,这是一个有前途的治疗选择.
- 这种组合改善了EGFR-TKI治疗的持续时间,并显示了通过ctDNA监测疗效的潜力.
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