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胆固醇和斯芬戈米林独特地改变了转氨酸聚合率,并降低了粉样纤维的毒性

Abid Ali1, Kiryl Zhaliazka1, Tianyi Dou1

  • 1Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.

The journal of physical chemistry letters
|November 30, 2023
PubMed
概括

胆固醇加快了跨甲基素 (TTR) 的聚合,而酸丁胆和甲基氨酸则抑制了它. 这些脂质改变了TTR纤维的结构和毒性,这表明它们在转胺氨基粉症的发展中发挥了作用.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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