在多肌性肌痛和巨细胞动脉炎中常见的并发病:英国生物银行的横截面研究
Charikleia Chatzigeorgiou1,2, John C Taylor1,3, Faye Elliott1
1School of Medicine, University of Leeds, Leeds, UK.
Rheumatology advances in practice
|November 30, 2023
概括
与对照组相比,多发性肌痛性风湿症 (PMR) 和巨细胞动脉炎 (GCA) 患者报告健康状况较差,并增加了高血压和白内障等并发症. 这些情况,特别是GCA,可能与葡萄糖皮质类药物治疗有关.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 临床医学 临床医学
背景情况:
- 多发性肌痛风湿症 (PMR) 和巨细胞动脉炎 (GCA) 是影响老年人的炎症状况.
- 了解相关的并发症对于全面的患者管理和确定潜在的治疗点至关重要.
研究的目的:
- 与匹配的对照组相比,调查诊断为PMR或GCA的患者的并发症的患病率.
- 确定PMR或GCA患者中更常见的特定健康状况.
主要方法:
- 一个嵌套的,横截面的病例控制研究使用来自英国生物库的数据进行.
- 40-69岁的参与者自我报告的PMR或GCA诊断与十个年龄,性别,种族和评估中心匹配的对照进行了比较.
- 条件后勤回归被用来分析病例状态和自我报告的并发症之间的关联.
主要成果:
- 与对照组相比,PMR/GCA病例报告的一般健康状况较差,情绪较低.
- PMR与甲状腺功能低下症和常用激素替代疗法 (HRT) 有关.
- 无论是PMR还是GCA,都显示出与高血压和白内障有显著的关联. GCA还表明与抑郁症有很强的关联. 这两种情况都与糖尿病无关.
结论:
- 患有PMR或GCA病史的个体体体验到自我评估的健康状况较差,无论目前使用葡萄糖皮质激素.
- 证实了与甲状腺功能低下症的确立关联,并确定了与高血压和白内障的新联系,特别是在GCA.
- 在PMR/GCA患者中,高血压和白内障的过度代表性可能受到长期葡萄糖皮质激素治疗的影响.
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