相关实验视频

Updated: Jul 9, 2025

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

ISX9装载的热敏纳米颗粒用于毛囊再生生长

Sapna Sayed¹, Mehdihasan Shekh², Jiaxing Song^1,3

¹Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, International Cancer Center, Department of Pharmacology, Shenzhen University Medical School, Shenzhen, China.

Materials today. Bio

|November 30, 2023

概括

一个新的温度敏感纳米粒子系统有效地传递ISX9以刺激毛囊再生. 这种先进的药物输送增强了Wnt/β-catenin信号传递,用于治疗雄激素性脱发症.

科学领域:

生物材料科学生物材料科学
皮肤病学皮肤病学
药物输送系统药物输送系统

背景情况:

雄激素性脱毛症需要有效的药物输送系统.
作为神经发生诱导剂的ISX9,通过Wnt/β-catenin信号传递促进毛囊的再生.
目前的主题ISX9交付有局限性.

研究的目的:

开发一种温度敏感,生物相容的纳米粒子系统,用于ISX9的交付.
为了提高ISX9在治疗脱发中的疗效.
调查该系统的通过皮肤传递潜力.

主要方法:

合成基托桑植入的多 ((glycidyl methacrylate-co-N-isopropyl acrylamide) (Poly ((GMA-co-NIPAAm) @CS-PGNCS) 和PF127核心纳米粒子.
纳米颗粒的热敏反应性质 (LCST在32°C) 和大小 (100-250nm) 的表征.
与局部ISX9.9相比,ISX9-载荷纳米粒子 (TBNP) 的体内评估.

主要成果:

在皮肤温度下控制ISX9释放的优化球形纳米粒子.
与局部ISX9.9相比,ISX9载的TBNP显示出比较优异的β-catenin,Wnt基因和HF标记物 (VEGF,TGF,IGF-1) 的上调.
与TBNP观察到的茎状和繁殖标志物的显著增强.

结论:

开发的TBNP提供了一个精确和有效的平台,用于通过皮肤传递ISX9.
该系统显示了通过促进毛囊再生来治疗雄性发育性脱发的潜力.
TBNP可以成为一种多功能平台,可以通过皮肤传递各种疏水药物.

关键词:

雄激素性脱毛症 (androgenetic alopecia) 是一种导致人脱毛的疾病.在ISX9上.纳米颗粒纳米颗粒通过皮肤传递药物.在Wnt/β-catenin路径中.

更多相关视频

Targeted Expression of GFP in the Hair Follicle Using Ex Vivo Viral Transduction

Targeted Expression of GFP in the Hair Follicle Using Ex Vivo Viral Transduction

Published on: March 17, 2008

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

相关概念视频

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...