探索系统免疫炎症指数 (SII),系统炎症反应指数 (SIRI) 和2型糖尿病视网膜病变之间的相关性
Shuqi Wang1,2, Xiaoyu Pan1,2, Boying Jia1,2
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|November 30, 2023
概括
系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 是2型糖尿病视网膜病变 (T2DR) 的潜在早期生物标志物. 更高的SII和SIRI水平表明T2DR的风险增加和诊断价值增加.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 2型糖尿病视网膜病变 (T2DR) 是2型糖尿病 (T2DM) 的重要并发症.
- 早期发现和诊断T2DR对于预防视力丧失至关重要.
- 需要新的生物标志物来改善T2DR诊断.
研究的目的:
- 调查SII,SIRI和T2DR之间的相关性.
- 评估SII和SIRI在T2DR中的诊断意义.
主要方法:
- 500名T2DM患者的回顾性分析 (256名非糖尿病视网膜病变[NDR],244名糖尿病视网膜病变[DR]).
- 在NDR和DR组之间计算和比较SII和SIRI值.
- 统计分析包括相关性,后勤回归和ROC曲线分析.
主要成果:
- 在DR组,SII和SIRI值显著较高 (P<0.001).
- SII和SIRI被确定为DR的独立风险因素.
- 结合SII和SIRI实现了高的诊断准确性 (AUC=0.782,灵敏度=74.6%,特异性=69.9%).
结论:
- SII和SIRI是T2DR的独立风险因素.
- 这些指数显示出T2DR诊断的早期生物指标的潜力.
- 结合SII和SIRI的使用可以提高T2DR的诊断准确度.
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