在老鼠中,肠道和脏适应了酸盐度的变化
Susana Lucea1, Gema Chopo-Escuin1, Natalia Guillén1
1Laboratory of Molecular Toxicology, Department of Biochemistry and Cell and Molecular Biology, University of Zaragoza, E50013 Zaragoza, Spain.
Function (Oxford, England)
|November 30, 2023
概括
在老鼠中, (P) 适应包括肠道和脏调节. 甲状腺激素 (PTH) 和纤维细胞生长因子23 (FGF23) 是关键激素,但它们与P运输和NaPi2a表达的相关性是复杂的.
科学领域:
- 身体生理学 身体生理学
- 脏生理学 脏生理学
- 胃肠道生理学 胃肠道生理学
背景情况:
- 饮食中的酸盐 (P) 稳态对于细胞功能至关重要.
- 肠道和脏在P的吸收和分泌中起着重要的作用.
- 激素调节,包括副甲状腺激素 (PTH) 和纤维细胞生长因子23 (FGF23),影响P平衡.
研究的目的:
- 研究肠道和脏酸盐 (P) 运输的适应机制,以应对不同的食度P.
- 阐明甲状腺上腺激素 (PTH) 和纤维细胞生长因子23 (FGF23) 在P适应中的作用.
- 检查NaPi2a蛋白表达的调节与P传输和荷尔蒙变化有关.
主要方法:
- 鼠 (正常和副甲状腺切除术) 接受了不同P度 (0.1%,0.6%,1.2%) 的食.
- 酸盐 (Pi) 吸收量测量在阴和脏刷边缘膜囊泡中.
- 在血液和尿液中分析了激素和离子度;评估了NaPi2a蛋白的丰度.
主要成果:
- 脊髓和脏的P传输适应了正常大鼠的慢性饮食P变化.
- 急性P适应在皮层比皮层更明显.
- PTH对状P适应不至关重要,而PTX大鼠的适应减少;NaPi2a表达在PTX脏中较高,但与饮食P相似.
- PTH和FGF23被饮食持续调节,即使在禁食期间.
- 在P运输,NaPi2a表达和PTH/FGF23水平之间观察到缺乏相关性.
结论:
- 酸盐 (P) 适应涉及肠道,脏和激素之间的复杂相互作用.
- 甲状腺激素 (PTH) 和纤维细胞生长因子23 (FGF23) 是关键的调节剂,但它们与P运输和NaPi2a的关系并不总是直接的.
- 对P适应的新见解揭示了载体功能,蛋白质表达和激素信号之间的解离.
相关概念视频
01:27Roles of Electrolytes: Calcium and Phosphate
288
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
The calcium concentration in blood plasma is primarily...
288
01:29Renal Regulation of Acid-Base Balance
468
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
468
01:11Renal Failure: Dose Adjustments
95
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
95
01:24Renal Tubule and Collecting Duct
1.0K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.0K
01:20Formation of Dilute Urine
1.6K
The formation of dilute urine is a critical renal adaptation that maintains fluid balance, particularly during periods of high fluid intake. This process primarily involves the juxtamedullary nephrons. By adjusting the permeability of water and ions in response to physiological conditions, the kidneys can either conserve or excrete water, resulting in concentrated or dilute urine.
Filtrate Osmolarity in the PCT
Initially, as the filtrate passes through the proximal convoluted tubule (PCT), its...
Filtrate Osmolarity in the PCT
Initially, as the filtrate passes through the proximal convoluted tubule (PCT), its...
1.6K
01:13Introduction to Urinary System
2.7K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
2.7K