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侧面化和衰老在皮质内刺激和抑制方面的显著影响

Zhongfei Bai¹, Feifei Zhu¹, Xiaoyu Lou¹

¹Department of Rehabilitation, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Centre), School of Medicine, Tongji University, Shanghai, China.

Frontiers in neuroscience

|November 30, 2023

概括

衰老显著影响原发动皮质 (M1) 中的皮质内刺激和抑制,在老年人中观察到皮质脊髓刺激性降低. 运动侧面化也会影响M1功能,但是老化会影响M1功能.

科学领域:

神经科学是一个神经科学.
发动机控制器的控制器
衰老研究研究衰老研究

背景情况:

在初级运动皮质 (M1) 中,皮内刺激和抑制对于运动控制至关重要.
关于M1神经生理学上的运动横向化和衰老影响的先前发现是不一致的.
通过电肌图 (TMS-EMG) 和电脑图 (TMS-EEG) 进行的跨磁刺激可以精确测量M1刺激能力.

研究的目的:

调查运动侧面化 (主导与非主导半球) 和衰老 (年轻人与老年人) 对M1.1内皮层刺激和抑制的独立和交互作用.
利用TMS-EMG和TMS-EEG来评估健康成年人的神经生理结果.

主要方法:

招募了21名年轻 (平均年龄为28.1岁) 和21名年长 (平均年龄为62.8岁) 的健康成年人.
记录了一组TMS-EMG测量和单脉冲TMS-EEG用于双边M1.
使用双向重复测量ANOVA分析神经生理结果,以评估横向化,衰老及其相互作用效应.

主要成果:

非主导的M1显示出更长的皮质静止期和更大的P60,N100和P180振幅.
年龄较大的参与者表现出皮质脊髓刺激性降低,由较高的静止运动值和较低的运动唤起电位幅度证明.
与年轻人相比,老年人减少了N100的振幅,并且N100和P180的延迟时间明显较晚.
没有发现横向化和衰老之间的显著相互作用效应.

结论:

运动侧向化和衰老对健康成年人M1内的皮质内刺激和抑制产生独立和显著的影响.
衰老与M1的刺激和抑制电路的功能下降有关.

关键词:

这就是TMS-EEG.衰老的衰老衰老的衰老皮层内抑制的抑制.横向化 (lateralization) 是一种侧向化.发动机唤起的潜在的电源.

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相关概念视频

Lateralization

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.