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病例报告: 一名患有延迟睡眠-觉醒阶段障碍和视神经低形成症的患者接受了tasimelteon治疗:一个案例研究

Sandra P Smieszek¹, Alyssa R Kaden¹, Caroline E Johnson¹

¹Vanda Pharmaceuticals Inc., Washington, DC, United States.

Frontiers in neuroscience

|November 30, 2023

概括

这项案例研究表明,tasimelteon有效地治疗了患有延迟睡眠-觉醒阶段障碍 (DSWPD) 和视神经低形成症 (ONH) 的患者. 治疗消除了DSWPD症状,并促进了患者延迟的睡眠-清醒周期.

科学领域:

神经科学是一个神经科学.
时间生物学时间生物学
眼科医生眼科眼科

背景情况:

延迟睡眠-觉醒阶段障碍 (DSWPD) 是一种昼夜节律障碍,其特点是持续延迟睡眠.
视神经低成形 (ONH) 是一种先天性疾病,可以影响视力,有时与其他发育问题有关.
经证实延迟的暗光黑激素发作 (DLMO) 表明身体内部时钟的错位.

研究的目的:

介绍一个患有DSWPD和ONH的成年女性成功用tasimelteon治疗的病例.
评估tasimelteon在缓解DSWPD症状和推进ONH患者的睡眠-清醒周期方面的疗效.

主要方法:

参与者被录取为期11个月的临床研究的开放式扩展期 (OLE).
治疗包括使用tasimelteon.
在整个研究过程中,监测了睡眠-清醒模式和DSWPD症状.

主要成果:

治疗Tasimelteon成功地解决了患者的DSWPD症状.
患者的睡眠-觉醒周期延迟显著提升.
参与者每晚都能获得足够的睡眠,而之前无法在他们想要的睡觉时间入睡.

结论:

塔西梅尔顿对于患有DSWPD的个人来说是一个可行的治疗选择,即使存在ONH.
这种药物有效地促进了昼夜节律,缓解了延迟睡眠的症状.
这一案例突显了药理干预对于复杂的昼夜节律障碍的潜力.

关键词:

延迟睡眠-觉醒阶段障碍延迟睡眠-觉醒阶段障碍视神经的低成形视神经的低成形生物节奏是生物节奏.昼夜节律障碍昼夜节律障碍临床试验研究研究临床试验研究睡眠延迟睡眠延迟一个夜猫头.睡眠/觉醒机制的发生.

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