在1年内对皮肤屏障和面部微生物组之间的相互作用进行了纵向研究
Jung Yeon Seo1, Seung Won You1, Ki-Nam Gu1
1Research and Innovation Center, R&D Center, LG H&H Co., Ltd., Seoul, Republic of Korea.
Frontiers in microbiology
|November 30, 2023
概括
皮肤微生物组的组成随着季节的变化而变化,在冬季和夏季观察到不同的细菌丰度. 像Cutibacterium这样的细菌的季节性变化与皮肤屏障功能相关,特别是皮肤间的水分流失 (TEWL).
科学领域:
- 微生物学 微生物学
- 皮肤病学 皮肤病学
- 环境科学 环境科学
背景情况:
- 皮肤是复杂的微生物生态系统,受环境因素的影响.
- 了解皮肤微生物组和宿主皮肤特征之间的动态相互作用对于皮肤健康至关重要.
研究的目的:
- 调查皮肤微生物组和关键皮肤生物物理参数 (TEWL,水分,弹性) 的季节性变化.
- 阐明季节性皮肤微生物变化与皮肤屏障功能之间的关系.
主要方法:
- 一年时间的长度研究 (2020年9月至2021年8月),共10名参与者.
- 分析皮肤微生物组组成 (属级) 和皮肤生物物理参数.
- 使用基因和基因组的京都百科全书 (KEGG) 的功能分析.
主要成果:
- 已经确定了主要的皮肤微生物属:Cutibacterium,Corynebacterium,Staphylococcus,Streptococcus和未分类的Neisseriaceae.
- 观察到的季节性波动:冬季菌更为丰富;夏季菌,葡萄球菌和链球菌更为丰富.
- 在Cutibacterium丰富度和跨皮肤流失 (TEWL) 之间发现了显著的关联,两者从冬季到夏季都在减少.
结论:
- 皮肤微生物组的组成表现出显著的季节性变化.
- 菌在维护皮肤屏障的完整性方面发挥着重要作用,尤其是在冬季.
- 季节性动态是影响皮肤微生物群及其与皮肤健康相互作用的关键因素.
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