在BCG疫苗接种后的结核素反应预测了肌缩性侧面硬化症风险
Ola Nakken1, Anders Myhre Vaage1,2, Hein Stigum3,4
1Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
Brain, behavior, & immunity - health
|November 30, 2023
概括
在BCG疫苗接种后,对结核素皮肤测试 (TST) 呈阴性T细胞反应与患有肌缩侧面硬化症 (ALS) 的风险较低有关. 这表明适应性免疫在ALS发展中起着关键作用.
科学领域:
- 免疫学 免疫学 免疫学
- 神经退行性疾病 神经退行性疾病
- 流行病学 流行病学
背景情况:
- 观察到T细胞透在肌缩侧面硬化症 (ALS) 中的运动神经元周围.
- 这种免疫反应在ALS发病过程中的作用 (原因或后果) 尚不清楚.
- 研究T细胞免疫反应的个体变异可能会阐明长期的ALS风险.
研究的目的:
- 为了确定T细胞免疫反应调节的变化是否与长期的肌缩性侧面硬化症 (ALS) 风险有关.
- 探索T细胞介导的免疫反应与ALS发展之间的联系.
主要方法:
- 使用结核素皮肤检测 (TST) 反应性BCG疫苗接种后作为T细胞反应的测量.
- 分析了挪威肺结核查计划 (1963-1975) 的数据,将TST结果与健康登记中的ALS诊断联系起来.
- 采用Cox的比例危险模型来评估结核素反应性和随后的ALS风险之间的关联.
主要成果:
- 一组324,629名参与者接受了结核查,496人后来被诊断出患有ALS.
- 与积极反应的人相比,具有负的TST反应的个体对ALS (0.74) 的危险比率较低.
- 这种TST反应性和ALS风险之间的关联已被观察到40多年,特别是当BCG疫苗接种和TST之间的时间很短时.
结论:
- 在BCG疫苗接种后,结核素皮肤测试的负答案与长期患有肌缩侧面硬化症 (ALS) 的风险降低相关.
- 这些发现支持了适应性免疫在ALS初级发展中的重要作用.
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