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奎尔素通过抑制细胞热致死来保护小鼠的诱导的损伤

Juyu Wang¹, Jieyan Yang¹, Kai Liu¹

¹Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.

Frontiers in veterinary science

|November 30, 2023

概括

这项研究表明,暴露会导致细胞亡. 类素保护脏通过抑制这种诱导的细胞死亡.

科学领域:

毒理学毒理学毒理学
腎臟病學 (nephrology) 是一種醫學專業.
细胞生物学细胞生物学

背景情况:

(Cd) 是一种有毒的重金属,影响脏健康.
奎尔是一种无毒的黄类化合物,通过抗氧化和抗亡机制减轻Cd诱导的损伤.
奎尔丁对Cd诱导的细胞灭的作用尚不清楚.

研究的目的:

调查奎尔在预防诱导的细胞灭中的作用.
阐明奎尔素在细胞中对毒性的保护机制.

主要方法:

建立了中毒的体外和体外模型.
在暴露于的模型中使用素.
评估了细胞活力,损伤标志物 (血尿素,GPX,SOD),组织病理学和与热死相关的蛋白质水平 (NLRP3炎症组,IL-1β,IL-18,caspase-1).

主要成果:

奎尔可以逆转引起的细胞活力下降.
暴露增加了血液尿素,降低了GPX和SOD,引起脏组织病理损伤,并增加了细胞热的标志物.
奎尔素的使用通过减少热亡,改善了这些诱导的损伤.

结论:

细胞容易受到暴露引起的热性细胞死亡.
奎尔素显示出对诱导的损伤的保护作用.
奎尔丁的保护机制涉及脏细胞灭的抑制.

关键词:

和是最重要的元素.损伤损伤损伤氧化应激是一种氧化应激.热灭症是什么?文素 (Quercetin) 是一种文素.

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