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Updated: Jun 27, 2026

An Oligonucleotide-based Tandem RNA Isolation Procedure to Recover Eukaryotic mRNA-Protein Complexes
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An Oligonucleotide-based Tandem RNA Isolation Procedure to Recover Eukaryotic mRNA-Protein Complexes

Published on: August 18, 2018

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一种增强的生物物理查策略,以调查ASO对其标RNA的亲和力

Rouven Stulz1, Michael Lerche2, Olivia Luige3,4

  • 1Oligonucleotide Chemistry, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca Gothenburg Sweden.

RSC chemical biology
|November 30, 2023
PubMed
概括

这项研究引入了一种具有成本效益的生物物理查方法,以精确测量抗意义寡核酸 (ASO) 与标RNA的结合. 这种增强的方法可以解释ASO的修改,改善RNA疗法的药物设计.

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相关概念视频

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...