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Updated: Jul 9, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
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Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

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设计者适配器蛋白质用于的功能转化为小分子体,以实现细胞内催化蛋白质修饰

Akiko Fujimura1, Hisashi Ishida2, Tamiko Nozaki1

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

ACS central science
|November 30, 2023
PubMed
概括

研究人员开发了一种联体插入的二叶酸减少酶 (eDHFR) 融合蛋白 (PLIED),使细胞透的合成功能小分子 (SFSM) 能够准感兴趣的蛋白质 (POI). 这种适配器允许精确的细胞内蛋白质修饰,扩展化学生物学工具.

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Regulated Protein Degradation

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Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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