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在口腔致癌的不同阶段,Cadherins switch和Caveolin-2的差异表达
Rebeca B Nascimento1, Isadora A R Machado1, Jamerson C Silva2
1PhD in Dentistry and Health, Department of Propaedeutics and Integrated Clinical, School of Dentistry, Federal University of Bahia, Salvador, Brazil.
Journal of oral and maxillofacial pathology : JOMFP
|November 30, 2023
概括
口腔状细胞癌的进展包括E-cadherin的减少和caveolin-2的增加. 这些变化,以及卡德林切换,可能作为口腔潜在恶性疾病和癌症的生物标志物.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物标志物发现发现
背景情况:
- 口腔状细胞癌 (OSCC) 是最常见的口腔恶性瘤,通常由口腔潜在恶性疾病 (OPMDs) 先发.
- 表皮介质转变 (EMT),以E-cadherin下调和N-cadherin上调为特征,在癌症进展中至关重要.
- 卡维奥林在细胞粘附和迁移中的作用表明它参与了瘤的攻击性行为.
研究的目的:
- 研究E-cadherin,N-cadherin和caveolin-2在口腔癌发生中的免疫表达.
- 确定潜在的生物标志物,用于预测口腔病变中的恶性潜在病变.
主要方法:
- 免疫组织化学用于评估正常口腔粘膜 (NOM),OPMD和OSCC标本中的E-cadherin,N-cadherin和caveolin-2表达.
- 临床病理学参数与蛋白质表达一起被评估.
主要成果:
- 随着口腔癌的进展,E-cadherin的免疫表达显著下降 (P=0.0018).
- N-cadherin表达在组之间没有显著差异,但一些OSCC病例缺乏E-cadherin.
- 卡维奥林-2的表达从NOM显著增加到OSCC (P=0.0028).
结论:
- 卡德林切换和增加的卡韦林-2表达与口腔癌发生有关.
- 这些标记物可能在口腔潜在恶性疾病向OSCC的进展中发挥调节作用.
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