低剂量阿司匹林和种族差异在低风险个体的自发早产
Veronica A Kane1, Maria Andrikopoulou2, Clara Bertozzi-Villa2,3
1Columbia University Vagelos College of Physicians and Surgeons, New York, NY (Ms Kane).
AJOG global reports
|November 30, 2023
概括
低剂量阿司匹林的使用减少了34周前自发早产的种族差异. 这一发现表明阿司匹林可能有助于解决不同种族群体中早产率的不平等问题.
科学领域:
- 产科和妇科 产科和妇科
- 围产期健康 围产期健康
- 健康差距 研究 研究 研究 研究
背景情况:
- 过早分娩是围产期发病率和死亡率的重要贡献者.
- 在美国,早产率的种族和民族差异仍然存在,黑人面临不成比例的更高风险.
- 关于低剂量阿司匹林对这些早产种族和民族差异的影响的数据有限.
研究的目的:
- 调查低剂量阿司匹林是否改变了种族/种族之间的关系以及自发早产风险.
- 分析低剂量阿司匹林对早产期种族差异的影响.
主要方法:
- 对一项随机临床试验的二次分析,该试验使用低剂量阿司匹林来预防低风险的无胎儿患者的孕前症.
- 参与者接受了60毫克的阿司匹林或安慰剂;排除包括多胎妊娠,胎儿异常和先前流产.
- 后勤回归模型评估了低剂量阿司匹林,种族/种族和自发早产 (<34周妊娠期) 之间的相互作用.
主要成果:
- 与白人和西班牙裔参与者相比,黑人参与者的自发早产率 (<34周) 比白人和西班牙裔参与者要高得多 (2.8%对1.2%,P=.04).
- 使用低剂量阿司匹林消除了黑人种族作为自发早产 (<34周) 的独立风险因素.
- 敏感性分析显示,在安慰剂组 (P=.01) 中,自发早产率因种族而异,但在低剂量阿司匹林组 (P=.90) 中没有.
结论:
- 低剂量阿司匹林的使用有效地缓解了在怀孕34周前自发早产中观察到的种族差异.
- 这些发现凸显了低剂量阿司匹林在减少早产不平等方面的潜力.
- 建议进行进一步的研究来证实和扩展这些结果.
关键词:
非洲裔美国人.黑色 黑色 黑色白色 白色 白色 白色 白色 白色卫生公平性健康公平性低剂量阿司匹林的使用.没有一对一的.胎盘疾病 胎盘疾病血小板聚合 血小板聚合孕前催产素前症候群是什么过早出生 过早出生种族和民族的差异.这是自发的早产.更多相关视频
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