与痛风性关节炎疾病活动相关的新炎症标志物:全身炎症反应指数
Yi Jiang1,2, Xin Tu1,3, Xia Liao1,2
1Research Center of Hyperuricemia and Gout, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People's Republic of China.
Journal of inflammation research
|November 30, 2023
概括
系统性炎症反应指数 (SIRI) 显示出作为痛风性关节炎 (GA) 疾病活动的新标志物的潜力. 较高的SIRI水平与急性痛风性关节炎相关,这表明其在评估GA患者炎症时的有用性.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 是新兴的非特异性炎症标志物.
- 没有先前的研究研究了SII和SIRI与痛风性关节炎 (GA) 疾病活动的关联.
研究的目的:
- 探索SII和SIRI与痛风性关节炎疾病活性之间的潜在关联.
- 评估SII和SIRI对急性痛风性关节炎 (AG) 的诊断价值.
主要方法:
- 横截面研究涉及474名急性痛风性关节炎 (AG) 患者,399名临界痛风性关节炎 (IG) 患者和194名健康对照人群 (HC).
- 评估的单细胞-淋巴细胞比率 (MLR),中性粒细胞-淋巴细胞比率 (NLR),血小板-淋巴细胞比率 (PLR),SII和SIRI水平.
- 在AG和IG组治疗前和治疗后分析了这些标记物的变化.
- 使用多变量后勤回归和ROC曲线来识别影响因素和AG的诊断价值.
主要成果:
- 与IG和HC组相比,AG组的红细胞沉积率 (ESR),C反应蛋白 (CRP),PLR,SII和SIRI显著更高.
- 在AG组治疗后,MLR,NLR,SII和SIRI显著下降.
- SIRI与ESR和CRP正相关.
- 鉴定出SIRI,ESR和CRP是急性痛风发作的影响因素,AUC分别为0.674,0.664和0.755.
结论:
- SIRI可以作为一种新的炎症标志物,用于评估痛风性关节炎的疾病活性.
- 这些发现表明SIRI在监测GA炎症和疾病进展方面的潜在作用.
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