一个常见的单核酸多态性与炎症和严重疾病的结果有关
Fayten El-Dehaibi1, Ruben Zamora1, Josiah Radder2
1Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
iScience
|November 30, 2023
概括
LYPD4基因的遗传变异,特别是rs10404939,会影响炎症,并预测严重疾病的结果. 这种常见的单核酸多态 (SNP) 可以根据患者的炎症反应和生存来分层患者.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 关键护理医学 关键护理医学
- 免疫学 免疫学 免疫学
背景情况:
- 危急疾病中的急性炎症是复杂的,并影响患者的结果.
- 遗传因素可能会导致炎症反应的异质性.
- 识别遗传标记可以帮助分层患者并预测预后.
研究的目的:
- 调查常见单核酸多态 (SNPs) 与严重疾病中的全身炎症调解者之间的关联.
- 为了确定遗传变异是否可以对患者的结果进行分层.
- 为了确定预测急性炎症异质性的特定基因变异.
主要方法:
- 全基因组关联研究 (GWAS) 分析了551,839个SNP.
- 系统性炎症媒介被评估与SNP相关.
- 在导出队列 (不的创伤) 和两个验证队列 (创伤和非创伤) 中进行分析.
主要成果:
- 在 LYPD4 基因中, rs10404939 被确定为一个显著的 SNP.
- 具有rs10404939AA基因型的创伤患者表现出不同的炎症轨迹和多个器官功能障碍 (MOD) 指数的升高.
- rs10404939AA验证队列中的同卵性异体具有更高的MOD指数,而非创伤患者的90天存活率与GG同卵性异体相比更差.
结论:
- rs10404939 SNP是一种常见的遗传变异,与严重疾病结局有关.
- 这种SNP可以根据炎症概况和预后对患者进行分层.
- rs10404939代表了严重疾病的广泛预后标记,突出了遗传变异性的作用.
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